1. Nevertheless, the senile plaques common in Alzheimer's disease are not found. 2. Senile plaques are extracellular aggregations of amyloid-b ( A? ) protein.3. The lesions are called " senile plaque " and " neurofibrillatory tangles ." 4. In the formation of senile plaques , A? is cleaved from the amyloid precursor protein. 5. AD is also classified as an amyloidosis because of the presence of senile plaques . 6. A correlation between the presence of senile plaques and Down syndrome has also been verified. 7. This should not be confused with the degree of senile plaque involvement, which progresses differently. 8. These A? aggregates then grow into significantly larger senile plaques , a pathological marker of Alzheimer's disease. 9. By the same mechanism it also raises concentrations of beta amyloid, the main constituent of senile plaques . 10. In patient's with Alzheimer's disease, beta-amyloid proteins form aggregates known as senile plaques , which disrupt neural functioning.
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